Evaluation of endocrine dysfunction in thalassemia intermedia
نویسندگان
چکیده مقاله:
Introduction: Thalassemia is an inherited disease which leads to an imbalance of globinchain synthesis and consequently, ineffective hematopoiesis. Iron deposits in many important body organs, as endocrine organs due to blood transfusion or ineffective hematopoiessis. The aim of the present study is to assess the endocrine disorders in the patients with thalassemia intermedia referred to the thalassemia center of Bandar-Abbas, Iran. Methods: Eighty-six patients with intermediate thalassemia attended the thalassemia center of Bandar-Abbas were enrolled in a cross-sectional, descriptive-analytic study. They were evaluated for demographic characteristics, past medical history, familial history and physically examined for sexual maturity and thyroid gland weight assessment. Then blood samples were taken to measure thyroid, parathyroid and sexual hormones. Fasting blood glucose, magnesium and ferritin levels were checked and were analyzed by SPSS 16.0. Results: There were 47 males (54.7%) and 39 females (45.3%). Frequency of hypoparathyroidism was 18.6%, diabetes mellitus 8.1%, sub-clinical hypothyroidism 4.65%, hypo-phosphatemia 29.06%, and hypo-magnesemia was 1.16%. Delayed puberty was found in 6.07% girls and, 4.7% boys. Primary amenorrhea was seen in 15.4% of female cases. Moreover, there was not a significant difference in hemoglobin rate between hypoparalhyaism and normal cases (P<0.05). Conclusion: It's recommended to evaluate the patients' suffering from thalassemia intermedia for diabetes mellitus, thyroid dysfunctions, parathyroid abnormality, and sexual maturity routinely.
منابع مشابه
Endocrine Function in Thalassemia Intermedia
UNLABELLED Thalassemias are the most common genetic disorder on a wordwide basis. β-thalassemia is a severe hemolytic anemia which results from genetic defects in the synthesis of the hemoglobin β-chain. Various endocrine abnormalities have been described in patients with thalassemia major. Endocrine disturbances have also been observed in patients with thalassemia intermedia (TI). In this stud...
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Abstract Background Thalassemia intermedia is a variety of beta thalassemia which shows clinical symptoms somewhere between asymptomatic carriers and thalassemia major. Cardiac dysfunctions due to chronic anemia and hemosiderosis are the major causes of death in these patients. The purpose of this study is to evaluate cardiac function in these patients by echocardiography. Materials and Met...
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متن کاملEvaluation of Cardiac Function in Patients with Thalassemia Intermedia
BACKGROUND Thalassemia intermedia is a variety of beta thalassemia which shows clinical symptoms somewhere between asymptomatic carriers and thalassemia major. Cardiac dysfunctions due to chronic anemia and hemosiderosis are the major causes of death in these patients. The purpose of this study is to evaluate cardiac function in these patients by echocardiography. MATERIALS AND METHODS This c...
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عنوان ژورنال
دوره 13 شماره None
صفحات 227- 233
تاریخ انتشار 2010-01
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